The early kick-off is between Cagliari and Udinese, two sides fighting to stay mid-table with the threat of the danger zone lurking.
It starts at 11.30 GMT, click here for a match preview.
Once again, only 5,000 fans are allowed into the Stadio Sant’Elia due to restructuring work at the venue.
Cagliari’s confidence gained a significant boost last week when they held Inter to a 1-1 draw at San Siro.
Daniele Conti and Albin Ekdal are suspended, so Andrea Cossu is again used in a deeper midfield role with January signing from Fiorentina Matias Vecino.
Adryan supports strikers Victor Ibarbo and Mauricio Pinilla.
Udinese must do without the banned Maurizio Domizzi and injured duo Andrea Lazzari and Igor Bubnjic.
Veteran Antonio Di Natale leads the way with renewed confidence, having admitted this week he might reconsider his decision to retire at the end of the season.
He has Bruno Fernandes in the second striker role, while 17-year-old homegrown talent Simone Scuffet is again picked in goal.
The Friulani have rediscovered their form and hope to extend their four-match unbeaten run.
Cagliari: Avramov; Pisano, Rossettini, Astori, Avelar; Dessena, Cossu, Vecino; Adryan; Ibarbo, Pinilla
Udinese: Scuffet; Heurtaux, Danilo, Naldo; Basta, Pinzi, Yebda, Pereyra, Gabriel Silva; Bruno Fernandes, Di Natale
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!