Inter and Torino both have to reshuffle their squads in an unexpected battle for European qualification.
It kicks off at San Siro at 14.00 GMT, click here for a match preview.
The Nerazzurri are unbeaten in four rounds and sit in fifth place, but they are only five points clear of the Granata in ninth.
President Erick Thohir is in the stands, as today is the 106th anniversary of Inter’s foundation, but so far he hasn’t been present to witness a single win.
Walter Mazzarri has to revamp his back three, as both Juan Jesus and Walter Samuel are suspended with Ricky Alvarez injured in midfield.
Andrea Ranocchia and Hugo Campagnaro are therefore drafted in and given a rare opportunity to shine.
Hernanes returns to the middle of the park after he missed out on last week’s 0-0 draw at Roma.
Torino also have huge problems at the back with Kamil Glik, Nikola Maksimovic and Cesare Bovo banned, while Salvatore Masiello, Giovanni Pasquale and striker Marcelo Larrondo are sidelined.
There is a boost with news Emiliano Moretti is able to start just 11 days after undergoing keyhole knee ligament surgery and Marko Vesovic makes his Serie A debut in midfield.
Ciro Immobile, who made his senior Italy debut on Wednesday, and Alessio Cerci lead the way, though Omar El Kaddouri is on the bench.
Torino haven’t beaten Inter, home or away, since 1994 with just five draws and 14 defeats with one clean sheet. However, they drew here 2-2 last season and in October played a spectacular 3-3 stalemate in Turin.
Inter: Handanovic; Rolando, Campagnaro, Ranocchia; Jonathan, Guarin, Cambiasso, Hernanes, Nagatomo; Icardi, Palacio
Inter bench: Castellazzi, Carrizo, Zanetti, Andreolli, Kovacic, Kuzmanovic, Botta, Taider, Milito, D’Ambrosio
Torino: Padelli; Darmian, Rodriguez, Moretti; Vesovic, Basha, Vives, Kurtic, Farnerud; Cerci, Immobile
Torino bench: Gomis, Berni, El Kaddouri, Barreto, Gazzi, Gyasi, Barreca, Aramu, Meggiorini, Tachtsidis
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more