Radja Nainggolan said Roma “cannot lose tonight” in their head-to-head for second place with Napoli.
It kicks off at 19.45 GMT, click here for the line-ups.
“We see that Juventus are going strong, so we are targeting second place and that means we cannot lose tonight,” the former Cagliari midfielder told Sky Sport Italia.
The Giallorossi played at the San Paolo last month in the Coppa Italia semi-final, suffering a 3-0 defeat.
“If we had made more of our first half chances, it would’ve been a different game. Therefore we have to ensure we convert our scoring opportunities.
“We will play the same way we always do, then of course against a strong side like Napoli and after losing 3-0 we have to learn from those mistakes and adapt.”
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!