Napoli want to keep their Serie A momentum going to chase down Roma in second, but Torino make shock changes.
It kicks off at 18.00 GMT, click here for a match preview.
Rafa Benitez again rotates his squad ahead of Thursday’s Europa League decider with Porto, where they must overturn a 1-0 first leg defeat.
Christian Maggio is out for around a month after emergency surgery on a collapsed lung, while Rafael and Juan Camilo Zuniga are long-term absentees.
Anthony Reveillere takes the right-back slot from Maggio, while Jorginho has recovered to start in midfield.
Dries Mertens, Marek Hamsik and Jose Callejon fan out behind Gonzalo Higuain, as Benitez hopes regular playing time can get the Slovak back to his old self.
Torino are without Giovanni Pasquale, Salvatore Masiello and Marcelo Larrondo, while Giuseppe Vives is suspended in midfield and makes way for Panagiotis Tachtsidis.
Toro had been a revelation of the campaign, but hit the skids recently with three consecutive defeats, failing to score a single goal. It’s a negative streak they had not experienced in Serie A since 2008.
Because of their poor form, Coach Giampiero Ventura has made a shock move, dropping both star strikers Alessio Cerci and Ciro Immobile in favour of Paulo Vitor Barreto and Riccardo Meggiorini.
Omar El Kaddouri starts against his parent club, as he is on loan to the Granata from Napoli.
This fixture has not ended in a stalemate since November 1995, while Torino’s last win was in December 2008.
Last season Edinson Cavani bagged a hat-trick in a spectacular 5-3 Napoli victory.
Torino: Padelli; Bovo, Glik, Moretti; Maksimovic, Kurtic, Tachtsidis, El Kaddouri, Darmian; Barreto, Meggiorni
Napoli: Reina; Reveillere, Fernandez, Albiol, Ghoulam; Inler, Jorginho; Mertens, Hamsik, Callejon; Higuain