Miroslav Klose, Federico Marchetti and Lucas Biglia are out of Lazio’s midweek trip to Genoa, as the German flies out for a specialist consultation.
The Serie A game kicks off on Wednesday at 19.45 GMT, click here for the match preview.
Klose was in the stands for Sunday’s 1-1 draw with Milan and is again ruled out completely by a back problem.
It’s reported he has flown out to Germany for a specialist consultation to discover why his back has been hurting so much of late.
Goalkeeper Marchetti is still out of action after missing the Milan game, so Etrit Berisha takes the gloves.
Midfielder Biglia is also sidelined with an injury, but Helder Postiga is one step closer to his Serie A debut.
Lazio squad for Genoa: Berisha, Strakosha, Guerrieri; Biava, Dias, Konko, Radu, Novaretti, Cavanda, Cana; Ledesma, Onazi, Mauri, Candreva, Gonzalez, Felipe Anderson, Crecco, Minala; Perea, Keita, Kakuta, Postiga