Roma rest Francesco Totti, but launch Alessandro Florenzi with Mattia Destro and Gervinho for their trip to Sassuolo.
It kicks off at 11.30 UK time (10.30 GMT), click here for a match preview.
On paper this game is an easy win for the Giallorossi, but Sassuolo already held them to a 1-1 draw earlier this season.
Rudi Garcia reshuffles after Tuesday’s late 2-1 victory over Torino, secured by substitute Alessandro Florenzi’s strike.
He rests captain Totti and Douglas Maicon, giving Florenzi and Vasilis Torosidis the chance to shine.
Kevin Strootman and Federico Balzaretti are long-term injury absentees.
Sassuolo are coming off two consecutive defeats that have left their chances of avoiding relegation very slim indeed.
Their home record is a big part of that, as they have lost 10 of their 15 games here and are five points adrift of safety.
Domenico Berardi hopes to inspire after his three-match ban, but Coach Eusebio Di Francesco – who spent much of his playing career at Roma – has a lengthy injury list.
Out of action are Antonio Floro Flores, Matteo Brighi, Thomas Manfredini, Luca Marrone, Raffaele Pucino, Marius Alexe, Paolo Bianco and Francesco Acerbi.
Sassuolo: Pegolo; Gazzola, Mendes, Cannavaro, Longhi; Biondini, Chibsah, Missiroli; Berardi, Floccari, Sansone
Sassuolo bench: Pomini, Polito, Antei, Ariaudo, Terranova, Ziegler, Rosi, Magnanelli, Masucci, Farias, Sanabria, Zaza
Roma: De Sanctis; Torosidis, Benatia, Castan, Romagnoli; Nainggolan, De Rossi, Pjanic; Florenzi, Destro, Gervinho
Roma bench: Lobont, Skorupski; Jedvaj, Toloi, Maicon, Taddei, Bastos, Ljajic, Mazzitelli, Ricci, Totti