Fiorentina have been losing momentum recently and need to get back on track against a decimated Udinese.
It kicks off at the Stadio Franchi at 14.00 UK time (13.00 GMT), click here for a match preview.
The Viola are still relatively comfortable in fourth place, but have picked up just one point from the last two rounds.
The injury crisis is undoubtedly affecting them, ruling out Juan Manuel Vargas, Giuseppe Rossi, Mario Gomez and Ante Rebic.
Stefan Savic is also suspended in defence and Borja Valero only fit for the bench, but David Pizarro and Manuel Pasqual have recovered to start.
Young Brazilian Ryder Matos gets a rare Serie A start with Josip Ilicic.
Udinese have their own problems to deal with, as top scorer Antonio Di Natale is out injured.
He’s joined on the treatment table by Gianpiero Pinzi, Maicosuel and Maurizio Domizzi.
Colombian international Luis Muriel therefore faces off against his fellow countryman Juan Guillermo Cuadrado.
Fiorentina: Neto; Tomovic, Rodriguez, Diakite; Cuadrado, Pizarro, Aquilani, Ambrosini, Pasqual; Matos, Ilicic
Fiorentina bench: Lupatelli, Rosati, Roncaglia, Compper, Bakic, Fernandez, Joaquin, Borja Valero, Wolski, Matri, Anderson
Udinese: Scuffet, Heurtaux, Danilo, Bubnjic; Widmer, Badu, Allan, Pereyra, Gabriel Silva; Bruno Fernandes, Muriel
Udinese bench: Brkic, Kelava, Gomes Edinaldo, Basta, Lopez, Jadson, Yebda, Lazzari, Zielinski. All. Guidolin
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