Carlos Tevez and Mirko Vucinic lead the way as Juventus host Lyon in the Europa League quarter-final.
The first leg saw the Bianconeri win 1-0 in France and this decider kicks off at the Juventus Stadium at 20.05 UK time (19.05 GMT).
Arturo Vidal returns from suspension in both Serie A and Europe to bolster the midfield, while Paul Pogba is rested in favour of Claudio Marchisio.
Andrea Barzagli and Angelo Ogbonna are still unavailable, so Martin Caceres again partners Leonardo Bonucci and Giorgio Chiellini.
It was Bonucci who scored the decisive goal at the Stade de Gerland last week.
Choosing Vucinic in attack suggests Antonio Conte has lost faith in Daniel Osvaldo, so his loan from Southampton will not be made permanent at the end of the season.
Tevez is hoping to break his extraordinary goal drought, as he has not scored in European competition since 2009, when he was wearing the Manchester United jersey.
Lyon need to score twice in order to go through to the semi-final, having lost 1-0 on home turf.
The injury crisis continues with Mouhamadou Dabo, Milan Bisevac, Gueida Fofana, Clement Grenier, Miguel Lopes and ex-Milan midfielder Yoann Gourcuff are sidelined.
Once again, Lyon start with Jimmy Briand and Alexandre Lacazette in attack, leaving Bafetimbi Gomis on the bench.
Juventus: Buffon; Caceres, Bonucci, Chiellini; Isla, Vidal, Pirlo, Marchisio, Asamoah; Tevez, Vucinic
Juventus bench: Storari, Ogbonna, Lichtsteiner, Pogba, Giovinco, Llorente, Osvaldo
Lyon: Lopes; Tolisso, B Kone, Umtiti, Bedimo; Malbranque, Ferri, Gonalons, Mvuemba; Briand, Lacazette
Lyon bench: Vercoutre, Zeffane, Bisevac, Danic, Fekir, Gomis, Njie
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!