Rafa Benitez reshuffles Napoli as he hosts a decimated Lazio with ex-San Paolo Coach Edy Reja at the helm.
It kicks off at 14.00 UK time (13.00 GMT), click here for a match preview.
The Partenopei’s confidence has been a rollercoaster over the past couple of weeks, as they went from beating Juventus 2-0 to losing at Parma.
Second place is now beyond reach, so they risk losing focus ahead of the Coppa Italia Final with Fiorentina on May 3.
Gonzalo Higuain starts and aims to end his five-game goal drought, the longest dry spell of his Napoli career so far.
Christian Maggio, Juan Camilo Zuniga and Rafael are still sidelined, so ex-Lazio man Goran Pandev faces his former club with Marek Hamsik and Jose Callejon rested.
It is rare that Benitez starts both Dries Mertens and Lorenzo Insigne, but he moves the local lad to the left wing with the captain's armband.
Lazio are still in the hunt for a Europa League spot, despite a series of problems and a civil war between club and fans.
Perhaps because of the empty stands at the Stadio Olimpico, the Biancocelesti have performed better away from home recently, where they cannot feel the boycott of their own ultras.
Reja is a familiar face in Naples, having taken this club from Serie C1 to the top flight when they resumed after bankruptcy.
He has precious few options available to him today, as Miroslav Klose, Keita Balde Diao, Federico Marchetti, Giuseppe Biava, Andre Dias, Alvaro Gonzalez and Ederson are all injured.
Lucas Biglia also sits out a ban in midfield, so Stefano Mauri has to become a makeshift striker with Felipe Anderson and Antonio Candreva.
Napoli: Reina; Henrique, Albiol, Britos, Ghoulam; Jorginho, Behrami; Mertens, Pandev, Insigne; Higuain
Lazio: Berisha; Konko, Ciani, Cana, Radu; Onazi, Ledesma, Lulic; Candreva, Mauri, Felipe Anderson