This afternoon in Sicily we could see Roma mathematically hand the Scudetto to Juventus or Catania go to Serie B.
It kicks off at the Stadio Massimino at 14.00 UK time (13.00 GMT), click here for a match preview.
If the Giallorossi fail to get all three points, then Juventus will be able to start the Scudetto party without kicking a ball against Atalanta on Monday.
Similarly, if Catania lose then they will be doomed to relegation into Serie B after eight years continually in the top flight.
Roma haven’t won in Catania since 1970-71, as the last away victory was in 2006-07 on neutral turf in Lecce.
Mattia Destro completes his four-match ban, while Radja Nainggolan is also suspended on his birthday, so Rodrigo Taddei starts.
Rafael Toloi joins Federico Balzaretti and Kevin Strootman on the injury list, forcing a revamp of the defence.
Leandro Castan and Mehdi Benatia are not 100 per cent fit either, so Alessio Romagnoli moves into central defence.
Gervinho is rested ahead of next week’s game with Juventus, so Alessandro Florenzi and Adem Ljajic support veteran captain Francesco Totti.
Catania are without the injured Mariano Andujar, Sergio Almiron and Giuseppe Bellusci.
After last night’s chaos around the Coppa Italia Final, in which a 48-year-old Roma ultra was arrested for attempted murder in shooting at Napoli fans, it’s reported Giallorossi supporters won’t travel to Sicily today.
There are fears of revenge attacks, as Catania and Napoli ultras are twinned.
Catania: Frison; Peruzzi, Rolin, Gyomber, Monzon; Izco, Lodi, Rinaudo; Barrientos, Bergessio, Castro
Roma: De Sanctis; Maicon, Romagnoli, Castan, Dodò; Pjanic, De Rossi, Taddei; Florenzi, Totti, Ljajic