Inter-Lazio is a showdown for Europa League qualification and San Siro’s final salute to Javier Zanetti after 19 years.
It kicks off at 19.45 UK time (18.45 GMT), click here for a match preview.
The Nerazzurri had seemed certain of a top six finish a few weeks ago, but a series of draws and the 1-0 defeat to Milan plunged them back into the danger zone.
Confidence is low and President Erick Thohir flew in this morning to be in the stands.
Juan Jesus is injured and Esteban Cambiasso suspended, but Ricky Alvarez is available on the bench with Zanetti.
It’s a very special night for 40-year-old Zanetti, who plays his final Serie A match at San Siro after 19 years at the club.
He’ll retire at the end of the season and has a special captain’s armband for the occasion. It reads ‘Javier Zanetti 4 Ever’ and has printed on it the names of all his teammates in the last two decades at Inter.
‘Pupi’ Zanetti will join the club staff next term and starts this game on the bench, but he will come on in the second half to salute the crowd.
Lazio have fumbled many opportunities to improve their Europa League credentials, but two consecutive 3-3 home draws against Torino and Verona leave them desperate for a victory tonight.
Senad Lulic sits out a ban with the injured Federico Marchetti, Abdoullay Konko, Stefan Radu, Helder Postiga and Ederson.
Miroslav Klose is back in the starting XI after a month out, partnering exciting ex-Barcelona teenager Keita Balde Diao and Brazilian Felipe Anderson.
Cristian Ledesma and Antonio Candreva are not 100 per cent fit, so start from the bench.
Inter: Handanovic; Ranocchia, Samuel, Rolando; Jonathan, Hernanes, Kuzmanovic, Kovacic, Nagatomo; Icardi, Palacio
Inter bench: Castellazzi, Carrizo, Zanetti, Andreolli, Campagnaro, D'Ambrosio, Alvarez, Guarin, Taider, Botta, Milito
Lazio: Berisha; Biava, Cana, Dias; Gonzales, Onazi, Biglia, Pereirinha; Felipe Anderson, Klose, Keita
Lazio bench: Strakosha, Guerrieri, Ciani, Elez, Novaretti, Mauri, Filippini, Pollace, Ledesma, Candreva, Perea, Minala