Lazio look to Miroslav Klose and Felipe Anderson against Milan’s Carlos Bacca and Alessio Cerci in this head-to-head for fifth place.
It kicks off in Rome at 19.45 GMT, follow the build-up and action on our LIVEBLOG.
There’s plenty at stake, because a win would propel Sinisa Mihajlovic’s men into sixth position, ahead of the Aquile.
If Lazio instead maintain their perfect home record so far this season in all competition, they’ll climb to fifth, just one point behind Napoli.
Stefano Pioli must do without injured Stefan de Vrij, who will be out for around four months after agreeing to knee surgery, Marco Parolo and Keita Balde Diao.
Veteran hitman Klose returns to lead the attack, supported by Felipe Anderson, Sergej Milinkovic-Savic and Antonio Candreva.
Milan again pick 16-year-old goalkeeper Gianluigi Donnarumma, who midweek kept their first clean sheet of the campaign.
Injuries rule out Mario Balotelli, Jeremy Menez and Ignazio Abate, but Mbaye Niang is on the bench for the first time since fracturing his foot in early August.
Cerci’s improving form sees him maintain his spot in the trident attack with Bacca and Jack Bonaventura, but Nigel De Jong is left out of midfield.
Mihajlovic has a poor record against his former club, managing only one win for Catania back in 2009-10. Since then he’s faced Lazio six times, emerging with just a single point.
Lazio have a 100 per cent record at the Olimpico in all competition this season.
They are also unbeaten here against Milan in five meetings, including three victories.
Lazio: Marchetti; Basta, Mauricio, Gentiletti, Lulic; Onanzi, Biglia; Candreva, Milinkovic-Savic, Felipe Anderson; Klose
Lazio bench: Berisha, Guerrieri, Braafheid, Radu, Hoedt, Konko, Cataldi, Mauri, Morrison, Onanzi, Djordjevic, Kishna, Matri
Milan: Donnarumma; De Sciglio, Alex, Romagnoli, Antonelli; Kucka, Montolivo, Bertolacci; Cerci, Bacca, Bonaventura
Milan bench: Abbiati, Diego Lopez, Calabria, Zapata, Mexes, Poli, De Jong, Jose Mauri, Suso, Honda, Niang, Luiz Adriano