Arkadiusz Milik and Dries Mertens step in as Napoli host Milan with Carlos Bacca aiming for another hat-trick.
It kicks off at the Stadio San Paolo at 19.45 UK time (18.45 GMT), follow the build-up and action on our LIVEBLOG.
The Partenopei started the season with a whimper, trailing 2-0 at newly-promoted Pescara until Mertens came off the bench to bag a quick-fire brace.
Because of that performance, the Belgian wizard is given a rare start in place of Lorenzo Insigne, partnering summer signing Milik.
Manolo Gabbiadini is on the bench after attempts to sell him to Everton or Fiorentina.
Milan risked throwing away their advantage against Torino, eventually winning 3-2 thanks to a Bacca hat-trick and last-gasp Gianluigi Donnarumma penalty save.
The 17-year-old goalkeeper made history today, becoming the youngest player to get a senior Italy call-up since 1911.
Gabriel Paletta is suspended, so Gustavo Gomez gets his Serie A debut in the Rossoneri defence.
Napoli: Reina, Hysaj, Albiol, Koulibaly, Ghoulam; Allan, Jorginho, Hamsik; Callejon, Milik, Mertens
Napoli bench: Rafael, Sepe, Strinic, Valdifiori, Maggio, Zielinski, Chiriches, Gabbiadini, L Insigne, Grassi, R Insigne, Laciski
Milan: Donnarumma; Abate, Gomez, Romagnoli, De Sciglio; Kucka, Montolivo, Bonaventura; Suso, Bacca, Niang
Milan bench: Diego Lopez, Gabriel, Vangioni, Antonelli, Ely, Calabria, Jose Mauri, Honda, Locatelli, Sosa, Luiz Adriano, Lapadula