Milan try to continue their remarkable climb to the top and could be Serie A leaders tonight, visiting a Genoa team on the slide.
It kicks off at 19.45 UK time (18.45 GMT).
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The midweek round begins with a great deal at stake, as Milan are fresh from beating Juventus and a win this evening would propel them to the top spot for at least 24 hours.
Genoa lost the Derby della Lanterna on Saturday and are therefore in dire need of a confidence-booster.
It’s a reunion for quite a few Rossoneri talents, as M’Baye Niang and Suso made their mark while on loan at Genoa.
Alessio Romagnoli and Coach Vincenzo Montella, on the other hand, are ex-Sampdoria men.