Udinese must win to be sure of the Europa League, while Inter face an early Coppa Italia start if they stumble again.
Milan know they must win in Siena to stave off Fiorentina and secure a Champions League spot, but they bench Stephan El Shaarawy.
The Derby del Sole sees Roma and Napoli go head-to-head, two of the most prolific and unpredictable teams in Serie A.
Fiorentina must beat already-relegated Pescara and hope Milan fail to get all three points in Siena to snatch third place.
Diamanti avoids fracture
Alessandro Diamanti is breathing a sigh of relief, as tests showed he has avoided a fracture in his wrist.
Report: Mazzarri to leave Napoli
Walter Mazzarri is widely expected to announce his exit from Napoli this evening, with Inter, Roma, Anzhi or even a rest period on the table.
PSG: 'Ancelotti wants Real Madrid'
Carlo Ancelotti “has asked us to leave for Real Madrid,” confirmed PSG director general Leonardo.
Diamanti to miss Confederations?
Alessandro Diamanti risks missing the Confederations Cup, as he is in hospital for X-Rays on his wrist.
Thereau: 'Fiorentina an honour'
Cyril Thereau bagged a brace for Chievo today and confirmed “it would be a great honour” to sign for Fiorentina.
Maresca: 'I'm leaving Samp'
Enzo Maresca has confirmed he will be leaving Sampdoria. “I am not part of their plans.”
Chievo thriller, Bologna shocker
Cyril Thereau snatched a last-gasp 2-2 draw for Chievo against Atalanta, but Bologna hit the woodwork twice as Genoa clung to a point.
Strama set for Under-21 job?
According to reports, Andrea Stramaccioni will take over the Italy Under-21 side if he is fired by Inter.
Bologna confirm 'friction' with Juve
Bologna confirmed there is “friction” in their rapport with Juventus, which is making talks for Alessandro Diamanti difficult.
Arsenal look to Lichtsteiner
Arsenal are said to be lining up a £12m offer for Juventus star Stephan Lichtsteiner.
Bianchi: 'Goodbye Torino'
Rolando Bianchi plays the final Torino match of his career today. “I want to embrace all the fans, one by one.”
Juventus lose Mattheus
Juventus look set to miss out on Mattheus, as he confirmed he is due to sign a renewal with Flamengo. “The deal didn’t happen.”
Milan look to Pjanic
Milan have reportedly set their sights on Roma midfielder Miralem Pjanic, facing competition from Spain and England.
Inter want Ince Junior?
Paul Ince played for Inter in the 1990s and now his son, Blackpool winger Thomas, could follow in his footsteps.
Pioli clings to Diamanti
Alessandro Diamanti is wanted by Juventus and Inter, but Bologna Coach Stefano Pioli is “hoping he stays here.”
Sannino unsure on Palermo
Palermo are doomed to Serie B and Coach Giuseppe Sannino won’t commit to next season yet. “I have to talk to the President.”
Juan Jesus: 'Next season will be better'
Inter end the campaign against Udinese tonight and Juan Jesus can’t wait for it to be over. “Next season will be better.”
Maran: 'Catania need top eight'
“Catania are determined to get eighth place,” insisted Coach Rolando Maran, as it can make a big difference to their Coppa Italia.
Iachini: 'Viola can count on Siena'
Siena are already relegated, but Beppe Iachini assures “we will play our game” against Milan, which is decisive for the Champions League.
Guidolin: 'Udinese's Scudetto'
Francesco Guidolin knows Udinese must beat Inter tonight to secure European qualification. “It’s our Scudetto.”
Serie A Previews: Final showdown
The season concludes this evening with European places up for grabs in Siena-Milan, Pescara-Fiorentina, Inter-Udinese, Cagliari-Lazio and Roma-Napoli.
What the papers say...
Today's front page headlines from La Gazzetta dello Sport, the Corriere dello Sport and Tuttosport.
Conte: 'Juve deserved more'
Antonio Conte feels Juventus “deserved more” from their two defeats to Sampdoria and wished Nicklas Bendtner all the best after his injury.
Rossi: 'Icardi will leave Samp'
Delio Rossi is the only Coach to have beaten Juventus twice this season, but admits “Mauro Icardi will leave Sampdoria.”
Samp beat Juve again!
Sampdoria beat Scudetto winners Juventus for the second time this year, but the 3-2 result had some controversial incidents.
Cassano in Monaco talks?
There are reports this evening that Antonio Cassano’s agent is having dinner with Monaco directors in Monte Carlo.
Marotta confirms Tevez talks
Beppe Marotta has confirmed Carlos Tevez’s agent approached Juventus. “We could reach an agreement with them.”
Serie B Play-Offs
The Serie B promotion play-offs begin on Wednesday May 22 with Brescia-Livorno and Novara-Empoli.
Juventus conclude their season at Marassi against the only team they haven’t been able to beat – Sampdoria.
Palacio returns for Inter-Udinese
Rodrigo Palacio is back in the Inter squad for tomorrow’s clash with Udinese, but Antonio Cassano and Andrea Ranocchia miss out.
Mandorlini: 'Verona, it's about time!'
Hellas Verona return to the top flight after 11 years and Coach Andrea Mandorlini said “it’s about time!”
TODAY'S FRONT PAGES
FOOTBALL ITALIA LATEST BLOGS
Cuadrado’s Florence farewell
The Cassano conundrum
Juve’s striking options
Selling Destro Roma’s mistake?
Thohir, Inter still on track
Serie A Week 20: Did You Know?
Player of Week 20: Marco Parolo
Mexes madness sadly symbolic
Mexes compounds Milan misery
Bon voyage, David Trezeguet
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