Rafa Benitez has included defensive starlet Felice Natalino in his starting line up for this evening's clash with Lazio.
The 18-year-old, who was recently called up to the Italy Under-21s, impressed as a substitute at the weekend.
Benitez also welcomes Sulley Muntari back into the fold while Goran Pandev starts as Inter's lone front man against his former club.
Lazio boss Edy Reja has made his intentions clear by starting with Mauro Zarate and Sergio Floccari in attack.
Brazilian playmaker Hernanes will be in the hole behind them supported by a midfield trio of Cristian Brocchi, Matuzalem and Stefano Mauri.
Lazio: Muslera; Lichtsteiner, Biava, Dias, Radu; Matuzalem, Brocchi, Mauri; Hernanes; Zarate, Floccari
Inter: Castellazzi; Natalino, Lucio, Cordoba, Zanetti; Deki, Cambiasso, Muntari; Biabiany, Sneijder; Pandev
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!