Cristian Chivu is expected to miss Inter's trip to Palermo after spraining his ankle during training today.
The Romanian international limped off early in the session with a sprained left ankle, though more tests are required to ascertain the extent of the damage.
It is unlikely Chivu can recover in time for Sunday night's Serie A opener against Palermo.
Ivan Cordoba, Douglas Maicon, Andrea Poli and Emiliano Viviano are also out due to injuries.
Thiago Motta is a major doubt after picking up a thigh problem during Italy's 1-0 win over Slovenia on Tuesday.
Inter announced that youth academy product Paolo Tornaghi, a goalkeeper who was on loan at Como, has been integrated into the senior squad.