Claudio Ranieri has named his first Inter line-up with Coutinho, Giampaolo Pazzini and Diego Forlan in Bologna.
The Coach makes his debut on the bench in the 17.00 UK time kick-off at the Stadio Dall'Ara.
He only took on his first training session on Thursday, as Gian Piero Gasperini was sacked following Tuesday's 3-1 defeat to Novara.
Ranieri has to do without the injured Wesley Sneijder, Dejan Stankovic, Ivan Cordoba, Douglas Maicon, Thiago Motta, Andrea Poli and Emiliano Viviano, while Andrea Ranocchia begins a three-match ban.
He has opted to throw Cicinho into the starting XI with Forlan, who is cup-tied for the Champions League, and the up until now ignored Pazzini.
As expected, Inter switch back to a 4-4-2 following Gasperini's unsuccessful attempts at a three-man defence.
Bologna picked up their first point of the campaign in a 1-1 draw away to Juventus on Wednesday evening and are hoping to register another upset.
Alessandro Diamanti and Jean-Francois Gillet passed last-minute fitness tests, though Andrea Raggi, Niccolo' Cherubin and Cruz were out of action.
Bologna: 1 Gillet; 16 Casarini, 90 Portanova, 5 Antonsson, 3 Morleo; 15 Perez, 26 Mudingayi, 33 Konè; 10 Ramirez, 23 Diamanti; 9 Di Vaio
Bologna bench: 25 Agliardi, 4 Krhin, 13 Pulzetti, 19 Vitale, 35 Paponi, 51 Loria, 99 Acquafresca
Inter: 1 Julio Cesar; 55 Nagatomo, 6 Lucio, 25 Samuel, 26 Chivu; 29 Coutinho, 4 Zanetti, 19 Cambiasso, 20 Obi; 7 Pazzini, 9 Forlan
Inter bench: 12 Castellazzi, 11 Alvarez, 22 Milito, 28 Zarate, 30 Castaignos, 42 Jonathan, 77 Muntari
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