Milan are forced to field Antonio Cassano and Stephan El Shaarawy in tonight's game with rock bottom Cesena.
Massimiliano Allegri had precious few options open to him when picking a starting XI at San Siro, kick-off 19.45 UK time.
The injury list includes Zlatan Ibrahimovic, Robinho, Alexandre Pato, Kevin-Prince Boateng, Luca Antonini, Daniele Bonera, Gennaro Gattuso, Massimo Ambrosini, Mathieu Flamini, Kingsley Boateng and Philippe Mexes.
This means the only two fully fit strikers available are Cassano and El Shaarawy, as Pippo Inzaghi has not played a whole game for 10 months.
Urby Emanuelson takes the trequartista role, while Taye Taiwo receives his Serie A debut in defence.
Cesena are the only side without a point so far this season, having lost to Napoli, Catania and Lazio.
Francesco Antonioli is still out of action, so Nicola Ravaglia takes the gloves, while Rafael Martinho joins Adrian Mutu and Antonio Candreva in attack.
Milan: Abbiati; Abate, Thiago Silva, Yepes, Taiwo; Nocerino, Van Bommel, Seedorf; Emanuelson; Cassano, El Shaarawy
Cesena: Ravaglia; Comotto, Von Bergen, Rodriguez, Marco Rossi; Martinez, Parolo, Guana; Martinho, Candreva, Mutu