Luis Enrique has Fabio Borini, Francesco Totti and Pablo Osvaldo taking on Parma's Sebastian Giovinco and Sergio Floccari.
The Giallorossi are still looking for their first win of the season and patience is running thin for the Spanish tactician's ideas.
They have been able to score only three goals in five official games, despite consistently rotating the front three.
Marco Borriello and Bojan Krkic are back on the bench, as Borini who joined Parma as a free agent over the summer faces his former teammates.
David Pizarro has been suffering from a back problem over the last few days, while Maarten Stekelenburg, Erik Lamela, Fernando Gargo and Leandro Greco are out of action.
Parma welcome back Giovinco from a one-match ban and he is their key player, as so far this season he has scored all of their goals.
Graziano Pelle and Francesco Valiano are sidelined, so Sergio Floccari partners the Atomic Ant.
Parma: 83 Mirante; 5 Zaccardo, 29 Paletta, 6 Lucarelli, 18 Gobbi; 7 Biabiany, 4 Morrone, 8 Galloppa, 23 Modesto; 10 Giovinco, 11 Floccari
Parma bench: 1 Pavarini, 3 Feltscher, 19 Rubin, 28 Jadid, 20 Blasi, 77 Ze Eduardo, 9 Crespo
Roma: 1 Lobont; 87 Rosi, 44 Kjaer, 5 Heinze, 3 Jose' Angel; 15 Pjanic, 16 De Rossi, 20 Perrotta; 31 Borini, 10 Totti, 9 Osvaldo
Roma bench: 18 Curci, 29 Burdisso, 11 Taddei, 77 Cassetti, 14 Bojan, 22 Borriello, 30 Simplicio
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.