Milan have Kevin-Prince Boateng back in the starting XI with Zlatan Ibrahimovic and Antonio Cassano against Sebastian Giovinco's Parma.
The match kicks off at San Siro this evening at 19.45 UK time as part of the Serie A midweek round.
Thiago Silva returns from an injury lay-off, but Alessandro Nesta has dropped out, so Daniele Bonera plays at centre-back.
Alexandre Pato, Gennaro Gattuso, Clarence Seedorf, Mathieu Flamini and Marco Amelia are out of action for the Rossoneri.
Coach Max Allegri does not rotate the squad, keeping faith with Cassano and Ibrahimovic, but Boateng starts after netting a hat-trick in the 4-3 win at Lecce when coming off the bench on Sunday.
Parma are still smarting from their 2-1 home defeat to Parma and miss Sergio Floccari, Alessandro Lucarelli and Manuele Blasi.
Rather than the expected Graziano Pellé, they pick Jaime Valdes as the partner for Giovinco.
There are changes elsewhere, including the introduction of Obiora Nwankwo and Rolf Feltscher.
Milan: Abbiati; Abate, Bonera, Thiago Silva, Taiwo; Aquilani, Ambrosini, Nocerino; Boateng; Ibrahimovic, Cassano
Parma: Mirante; Zaccardo, Paletta, Feltscher, Gobbi; Valiani, Morrone, Nwankwo, Modesto; Giovinco; Valdes
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £5,000 monthly.