Roma have Bojan Krkic, Erik Lamela and Fabio Borini as the trident against Rodrigo Palacio's Genoa.
The Giallorossi have to do without the injured Francesco Totti, Miralem Pjanic, Simon Kjaer, Cicinho and Aleandro Rosi.
Lamela keeps his starting spot after scoring on his Roma debut in the 1-0 win over Palermo on Sunday, but Pablo Daniel Osvaldo and Marco Borriello are benched.
Genoa have Palacio leading the way with support from Bosko Jankovic and Alexander Merkel, who impressed so much in Saturday's 2-2 draw with Juventus.
Genoa: 1 Frey; 20 Mesto, 3 Dainelli, 24 Moretti, 23 Antonelli, 7 Rossi, 4 Veloso, 14 Seymour, 52 Merkel; 8 Palacio, 11 Jankovic
Genoa bench: 22 Lupatelli, 5 Granqvist, 21 Bovo, 33 Kucka, 19 Jorquera, 99 Caracciolo, 10 Birsa
Roma: 24 Stekelenburg; 20 Perrotta, 29 Burdisso, 5 Heinze, 3 Jose Angel: 7 Pizarro, 16 De Rossi, 19 Gago; 8 Lamela; 14 Bojan, 31 Borini
Roma bench: 18 Curci, 4 Juan, 11 Taddei, 23 Greco, 77 Cassetti, 9 Osvaldo, 22 Borriello
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