Gigi Buffon and Mirko Vucinic start for Juventus, facing Inter's Wesley Sneijder, Mauro Zarate and Giampaolo Pazzini.
The tension is sky high for the Derby d'Italia, kick-off at 19.45 UK time, as a long history of animosity exists between these clubs.
Juve are alone on top of the table for the first time since the 2006 Calciopoli trial and hope to receive an answer next week from the tribunal ruling on the 2004-05 and 2005-06 Scudetti.
Emanuele Giaccherini is injured, but Buffon passed a late fitness test to start in goal despite his bruised shoulder.
Vucinic also gets the nod with Alessandro Matri and Arturo Vidal in what looks to be a 4-1-4-1 system.
Claudio Ranieri was famously fired by Juventus with just two weeks left in the campaign and now faces his former club at the helm of Inter.
He has to do without Diego Forlan, Julio Cesar, Andrea Ranocchia, Walter Samuel, Thiago Motta, Philippe Coutinho, Andrea Poli and Emiliano Viviano.
Sneijder is the trequartista behind Zarate and Pazzini, while Joel Obi is a surprise pick in midfield.
Luca Castellazzi takes over in goal after Julio Cesar's thigh strain.
Inter: 12 Castellazzi; 13 Maicon, 6 Lucio, 26 Chivu, 55 Nagatomo; 4 Zanetti, 19 Cambiasso, 20 Obi; 10 Sneijder; 28 Zarate, 7 Pazzini
Inter bench: 21 Orlandoni, 2 Cordoba, 5 Stankovic, 11 Alvarez, 22 Milito, 30 Castaignos, 42 Jonathan
Juventus: 1 Buffon; 26 Lichtsteiner, 19 Bonucci, 15 Barzagli, 3 Chiellini; 21 Pirlo; 7 Pepe, 22 Vidal, 8 Marchisio, 14 Vucinic; 32 Matri
Juventus bench: 30 Storari, 5 Pazienza, 10 Del Piero, 11 De Ceglie, 17 Elia, 18 Quagliarella, 28 Estigarribia