Robinho, Zlatan Ibrahimovic, Kevin-Prince Boateng and Taye Taiwo start as Milan visit BATE Borisov this afternoon.
The Rossoneri are in Belarus, so due to the time difference the match kicks off at 17.00 UK time.
Antonio Cassano is still in hospital after a mystery illness, while Alexandre Pato, Luca Antonini, Philippe Mexes, Gennaro Gattuso and Mathieu Flamini are among the absentees.
With Pippo Inzaghi and Stephan El Shaarawy off the UEFA list, Robinho and Ibrahimovic are the only available strikers.
Boateng has also shaken off a knock to start in the trequartista role, while Taiwo is picked at left-back in place of Antonini.
BATE Borisov have left Mateja Kezman on the bench at the Dinamo Stadion in Minsk and are looking for their first win of the season, having only one point in the table.
BATE Borisov: Gutor, Yurevich, Radkov, Simic, Bordachev, Volodko, Likhtarovic, Kontsevoi, Bressan, Baga, Skavysh
BATE bench: Chesnovski, Gordeychuk, Pavlov, Olekhnovich, M Volodoko, Rudik, Kezman
Milan: Abbiati; Abate, Nesta, Thiago Silva, Taiwo; Aquilani, Ambrosini, Nocerino; Boateng; Ibrahimovic, Robinho
Milan bench: Amelia, Bonera, De Sciglio, Yepes, Seedorf, Emanuelson, Ganz