Inter have Giampaolo Pazzini and Diego Milito together, but Fiorentina have lost Stevan Jovetic again.
The Nerazzurri need to get back on track after a disastrous run of two consecutive defeats in all competition.
Captain Javier Zanetti is suspended after the first red card of his Serie A career, joining the injured Diego Forlan, Wesley Sneijder, Dejan Stankovic, Jonathan, Joel Obi, Cristian Chivu and Emiliano Viviano.
Douglas Maicon returns at right-back from his injury and Marco Davide Faraoni is again picked in midfield, while Pazzini and Milito are the front two.
Fiorentina have been revived since Delio Rossi took over, particularly with last week’s 3-0 win over Roma.
Riccardo Montolivo, Mattia Cassani, Alessio Cerci and Per Kroldrup were out of action, but Jovetic was a last-minute addition to the injury list after picking up a hip problem.
This means Alberto Gilardino is supported by Adem Ljajic and Andrea Lazzari.
Inter: 1 Julio Cesar, 13 Maicon, 6 Lucio, 25 Samuel, 55 Nagatomo; 37 Faraoni, 8 Thiago Motta, 19 Cambiasso, 29 Coutinho; 7 Pazzini, 22 Milito
Inter bench: 12 Castellazzi, 2 Cordoba, 11 Alvarez, 18 Poli, 28 Zarate, 30 Castaignos, 77 Muntari
Fiorentina: 1 Boruc; 29 De Silvestri, 5 Gamberini, 14 Natali, 23 Pasqual; 85 Behrami, 20 Munari, 21 Lazzari, 6 Vargas; 22 Ljajic; 11 Gilardino
Fiorentina bench: 89 Neto, 10 Silva, 13 Kharja, 15 Nastasic, 17 Salifu, 28 Romizi, 92 Romulo