Roma have lost both Mirko Vucinic and Marco Cassetti for tonight's big Serie A match with Milan.
Full-back Cassetti was originally named in the squad travelling to San Siro, but dropped out after coming down with a flu virus.
It is another blow for Claudio Ranieri, who also has to do without hitman Vucinic due to an injury.
Julio Sergio and Juan are back in the side, but Bogdan Lobont and Simone Perrotta remain on the treatment table.
Roma squad: Cicinho, Castellini, Juan, Mexes, Pizarro, Adriano, Totti, Taddei, De Rossi, Riise, Borriello, Greco, Julio Sergio, Burdisso, Fabio Simplicio, Doni, Brighi, Alex, Rosi, Okaka, Menez