Mirko Vucinic and Alessandro Matri lead the way against Cagliari, as Paolo De Ceglie replaces Giorgio Chiellini for Juventus.
The Bianconeri aim to break away at the top of the table this weekend, hoping to take advantage of tonight’s Milan derby.
New buy Marco Borriello is on the bench for the first time since his loan move from Roma and wears shirt number 23, but it is Simone Pepe, Vucinic and ex-Cagliari striker Matri who start in the 4-3-3 system.
De Ceglie gets a rare chance to shine in place of the suspended Chiellini. Emanuele Giaccherini and Fabio Quagliarella are injured, the latter undergoing surgery for a fractured cheekbone this week.
Cagliari are fresh from a surprise 3-0 win over Genoa, but no opponent has scored at the Juventus Stadium since Fiorentina on October 25.
The Sardinians are without Gabriele Perico, Nene and Sebastian Eriksson, but Joaquin Larrivey gets the starting spot along with Victor Ibarbo and Andrea Cossu. This is their first game since selling Davide Biondini to Genoa.
Juventus:Buffon; De Ceglie, Barzagli, Bonucci, Lichtsteiner; Marchisio, Pirlo, Vidal; Pepe, Matri, Vucinic
Juventus bench:Storari, Sorensen, Marrone, Estigarribia, Krasic, Borriello, Del Piero.
Cagliari: Agazzi; Pisano, Canini, Astori, Agostini; Dessena, Ekdal, Nainggolan; Cossu; Larrivey, Ibarbo.
Cagliari bench: Avramov, Ariaudo, Gozzi, Conti, Ceppelini, Thiago Ribeiro, El Kabir