Inter have changed their tactics in Lecce, fielding Wesley Sneijder behind Giampaolo Pazzini and Diego Milito.
Claudio Ranieri had adopted a 4-4-2 system in the last few weeks, which proved successful when notching together a run of seven consecutive Serie A victories.
However, Sneijder’s return to fitness means the trequartista role is rediscovered, sending Ricky Alvarez to the bench.
Dejan Stankovic, Diego Forlan, Philippe Coutinho and Sulley Ali Muntari are still absent.
Lecce are still looking for their first home win of the season and were beaten 4-1 at San Siro in December.
Coach Serse Cosmi has to do without Moris Carrozzieri, Manuel Giandonato, Andrea Esposito and Julio Sergio.
Luis Muriel partners David Di Michele with Ruben Olivera starting in midfield despite reports of an imminent move to Fiorentina.
New signing Martin Miglionico goes straight into the starting XI, while ex-Viola man Haris Seferovic is on the bench.
Lecce: Benassi; Oddo, Miglionico, Tomovic; Cuadrado, Giacomazzi, Blasi, Olivera, Brivio; Muriel, Di Michele
Lecce bench: Petrachi, Diamoutene, Obodo, Grossmuller, Piatti, Seferovic, Bertolacci
Inter: Julio Cesar; Maicon, Lucio, Samuel, Nagatomo; Zanetti, Cambiasso, Obi; Sneijder; Pazzini, Milito
Inter bench: Castellazzi, Cordoba, Alvarez, Ranocchia, Chivu, Poli, Zarate
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!