Inter have Wesley Sneijder, Diego Milito and Diego Forlan for the crucial second leg as they try to overturn a 1-0 defeat to Olympique Marseille.
The Nerazzurri lost the first leg 1-0 with the final touch of the game in France, but hope to build on Friday’s 2-0 win over Chievo – ending a run of two points from nine official outings.
Cristian Chivu is suspended, joining the injured Ricky Alvarez in the stands. Andrea Ranocchia makes a surprise recovery for a spot on the bench.
Sneijder starts behind strikers Forlan and Milito, while Andrea Poli and Dejan Stankovic get the midfield nod ahead of Esteban Cambiasso.
If Inter have turned a corner, then Marseille are still spiralling with four consecutive Ligue 1 defeats in which they failed to score a single goal.
Coach Didier Deschamps welcomed back Stephane Mbia, Loic Remy and Mathieu Valbuena from injury at the weekend and they all start at San Siro, though Andre-Pierre Gignac is out with a thigh problem.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 25 Samuel, 55 Nagatomo; 4 Zanetti, 5 Stankovic, 18 Poli; 10 Sneijder; 9 Forlan, 22 Milito
Inter bench:12 Castellazzi, 23 Ranocchia, 37 Faraoni, 19 Cambiasso, 20 Obi, 7 Pazzini, 28 Zarate
Olympique Marseille: 1 Mandanda; 2 Azpilicueta, 21 Diawara, 3 N'Koulou, 15 Morel; 4 Diarra, 17 Mbia, 18 Amalfitano, 28 Valbuena, 20 A Ayew, 11 Remy
Marseille bench: 1 Bracigliano, 13 Traoré, 24 Fanni, 7 Cheyrou, 12 Kaboré, 9 Brandao, 23 J Ayew