Napoli have their Three Tenors to make history at Stamford Bridge against Roberto Di Matteo’s Chelsea.
At 19.45 UK time the second leg of this Champions League clash kicks off in London and the Partenopei have a 3-1 first leg advantage.
Andre Villas-Boas was on the bench at the San Paolo, but has been sacked, so Di Matteo makes his Champions League management debut.
Raul Meireles is suspended, while Jose Bosingwa is out injured.
Didier Drogba is picked ahead of Fernando Torres for the centre-forward role, while Daniel Sturridge gets the nod instead of Solomon Kalou. They are supported by Frank Lampard and Juan Mata.
Napoli have a full squad at their disposal, missing only Gianluca Grava.
The Three Tenors are out in force, so Edinson Cavani, Ezequiel Lavezzi and Marek Hamsik start in attack.
There were doubts over who would take the left flank and Juan Camilo Zuniga has won ahead of Andrea Dossena.
Chelsea:Cech; Ivanovic, Terry, David Luiz, A Cole; Ramires, Essien; Lampard, Juan Mata, Sturridge; Drogba
Chelsea bench: Turnbull, Cahill, Bosingwa, Mikel, Malouda, Kalou, Torres
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Gargano, Inler, Zuniga; Hamsik, Lavezzi; Cavani
Napoli bench: Rosati, Britos, Fernandez, Dzemaili, Dossena, Pandev, Vargas