It's Alexis Sanchez and Antonio Di Natale against Samuel Eto'o and Goran Pandev, as Udinese welcome Inter in the lunchtime kick-off.
The 11.30 UK time start at the Stadio Friuli should be a highly entertaining encounter, as both sides have been banging in the goals in 2011.
Leonardo aims to maintain his 100 per cent record since taking over from Rafa Benitez, but is still without Julio Cesar, Wesley Sneijder, Coutinho, Diego Milito and Walter Samuel.
Pandev is therefore picked to partner Eto'o with support from Dejan Stankovic.
Udinese have held Milan to a 4-4 draw and beaten Genoa 4-2 in their last couple of Serie A outings.
It's a special game for Sanchez, who has been repeatedly linked with a transfer to Inter.
He partners hitman Di Natale with midfield danger coming from Mauricio Isla, Gokhan Inler and Pablo Armero.
Dusan Basta, Damiano Ferronetti and Gabriele Angella are in the stands due to injury, but Maurizio Domizzi has recovered in time to start.
Udinese: 1 Handanovic; 17 Benatia, 2 Zapata, 11 Domizzi; 3 Isla, 66 Pinzi, 88 Inler, 20 Asamoah, 27 Armero; 7 Sanchez, 10 Di Natale
Udinese bench: 6 Belardi, 13 Coda, 26 Pasquale, 19 Badu, 23 Abdì, 16 Denis, 9 Corradi
Inter: 12 Castellazzi; 13 Maicon, 6 Lucio, 2 Cordoba, 26 Chivu; 4 Zanetti, 19 Cambiasso, 8 Thiago Motta; 5 Stankovic; 27 Pandev, 9 Eto'o
Inter bench: 21 Orlandoni, 15 Ranocchia, 23 Materazzi, 39 Santon, 17 Mariga, 20 Obi, 88 Biabiany
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition - £10,000 to be won!