Napoli have their full-strength side with Edinson Cavani against Liverpool, while Sampdoria make changes in a crunch match with Metalist.
The Europa League Matchday 4 concludes with the games kicking off at 20.00 UK time.
Anfield Road hosts the big Group K clash between the Partenopei and Liverpool, who drew 0-0 at the San Paolo two weeks ago.
Walter Mazzarri has no real injury concerns, so is able to field a full-strength side with Cavani supported by Ezequiel Lavezzi and Marek Hamsik.
Liverpool are again beset by problems, as Fernando Torres, Dirk Kuyt, Joe Cole and Daniel Agger are among the absentees.
However, Steven Gerrard is on the bench ready to come on, while Glen Johnson and Raul Meireles are in the starting XI.
Sampdoria are on the verge of elimination from the Europa League and need a victory tonight against Metalist.
They lost 2-1 in Ukraine against 10 men, where Taison was sent off and is therefore suspended for this match.
Obviously the Blucerchiati have frozen out Antonio Cassano, so Nicola Pozzi partners Guido Marilungo, in for the rested Giampaolo Pazzini, while Franco Semioli, Fernando Tissone and Gianluca Curci are injured.
Liverpool: Reina; G Johnson, Carragher, Kyrgiakos, Konchesky; Spearing, Poulsen; Jovanovic, Raul Meireles, Shelvey; Ngog
Liverpool bench: Hansen, Gerrard, Lucas, Wilson, Kelly, Skrtel, Ecclestone
Napoli: De Sanctis; Campagnaro, Cannavaro, Aronica; Maggio, Gargano, Pazienza, Dossena; Lavezzi, Hamsik; Cavani
Napoli bench: Gianello, Cribari, Santacroce, Grava, Zuniga, Yebda, Sosa, Dumitru
Sampdoria: Da Costa; Cacciatore, Gastaldello, Volta, Ziegler; Dessena, Poli, Palombo; Guberti; Pozzi, Marilungo
Sampdoria bench: Florillo, Zauri, Lucchini, Sammarco, Mannini, Koman, Pazzini
Metalist: Disljenkovic; Villagra, Gueye, Obradovic, Fininho; Bordian, Valyayev, Edmar, Olynyk; Devic, Cleiton Xavier
Metalist bench: Startsev, Romanchuk, Pshenychnykh, Berezovchuk, Kaita, Shelayev, Vorobey
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!