Inter and Roma are going on the attack with Giampaolo Pazzini, Samuel Eto'o and Wesley Sneijder against Marco Borriello, Mirko Vucinic and Jeremy Menez.
It is a head-to-head in the Scudetto race and for Champions League places, not to mention a rivalry that has dominated Italian football over the past five years.
The Nerazzurri have won all but one of their games under Leonardo and he again picks a very attacking line-up.
Dejan Stankovic, MacDonald Mariga, Lucio, Luca Castellazzi, Walter Samuel and the suspended Cristian Chivu are unavailable.
Sneijder is back to full fitness, so he starts behind Eto'o and January signing Pazzini.
At the back, ex-Cesena defender Yuto Nagatomo was expected to make his Inter debut, but is left on the bench in favour of Javier Zanetti.
Roma are also forced into changes, as Francesco Totti has stayed behind with a fever, joining the injured David Pizarro, Matteo Brighi and Adriano.
The same flu virus that ruled out Totti is also affecting Simone Perrotta, but he has been passed fit to start.
Philippe Mexes sits out a two-match ban for insulting the officials, so Juan and Nicolas Burdisso take on the centre-back roles.
Inter: 1 Julio Cesar; 13 Maicon, 15 Ranocchia, 2 Cordoba, 4 Zanetti; 15 Kharja, 8 Thiago Motta, 19 Cambiasso; 10 Sneijder; 7 Pazzini, 9 Eto'o
Inter bench: 12 Castellazzi, 20 Obi, 22 Milito, 23 Materazzi, 27 Pandev, 29 Coutinho, 55 Nagatomo
Roma: 27 Julio Sergio; 77 Cassetti, 29 N Burdisso, 4 Juan, 17 Riise; 20 Perrotta, 16 De Rossi, 30 Simplicio, 94 Menez; 22 Borriello, 9 Vucinic
Roma bench: 32 Doni, 3 Castellini, 11 Taddei, 15 Loria, 23 Greco, 33 Brighi, 87 Rosi
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition - £11,000 to be won monthly!