Napoli field a trident of Ezequiel Lavezzi, Giuseppe Mascara and Edinson Cavani against Giuseppe Rossi's Villarreal.
The Partenopei welcome the Spaniards to the packed out Stadio San Paolo for a 18.00 UK time kick-off this evening in the Europa League.
It will be the first time Napoli have played in a European springtime fixture since winning the 1988-89 UEFA Cup Final, but are this season Italy's only remaining Europa League representatives.
Their only injury absentees are Gianluca Grava and Luigi Vitale, so Coach Walter Mazzarri has practically a full squad to choose from.
Most importantly, Lavezzi's ban only stands for Serie A, so he is available in European competition to partner Cavani and new buy Mascara.
Villarreal have Italian international Rossi back in the side after an injury spell to start alongside Brazilian Nilmar.
Claudio Marchena and former Roma full-back Cicinho are on the bench.
Napoli: De Sanctis; Campagnaro, Cribari, Aronica; Maggio, Gargano, Yebda, Dossena; Lavezzi, Mascara; Cavani
Napoli bench: Iezzo, Ruiz, Pazienza, Santacroce, Hamsik, Zuniga, Sosa
Villarreal: Diego Lopez; Mario Gaspar, Gonzalo, Musacchia, Capdevila; Borja Valero, Senna, Bruno Soriano, Santi Cazorla; Nilmar, Rossi
Villarreal bench: Marino, Marchena, Marco Ruben, Cani, Catala, Cicinho, Gullon