Luca Toni and Alessandro Matri lead the way for Juventus against a completely reshuffled Lecce.
The 11.30 UK time kick-off is at the Stadio Via del Mare, as the Bianconeri try to continue their upturn in form.
Momo Sissoko sits out a ban, while Leandro Rinaudo, Paolo De Ceglie, Fabio Quagliarella and Simone Pepe are sidelined.
Coach Gigi Del Neri again sticks with Toni and Matri in attack, leaving captain Alessandro Del Piero on the bench.
Lecce are forced to reshuffle due to a series of bans, as Gustavo, Ruben Olivera, Nelson Jeda and Guillermo Giacomazzi are all suspended.
With Alberto Giuliatto, Edward Ofere and Nenad Tomovic injured, the choices are limited for Gigi De Canio.
He has chosen David Di Michele as the lone striker in a 4-1-4-1 system with Giuseppe Vives between the lines.
De Canio has to watch from the stands, as he is also suspended after insulting the referee last week.
Lecce: Rosati; Donati, Fabiano, Ferrario, Brivio; Vives; Munari, Bertolacci, Grossmuller, Mesbah; Di Michele
Juventus: Buffon; Sorensen, Bonucci, Barzagli, Chiellini; Krasic, Melo, Aquilani, Marchisio; Matri, Toni