Vincenzo Iaquinta, Alessandro Matri, Marco Storari and Jorge Martinez start as Juventus welcome Bologna.
The 19.45 UK time kick-off is at the Stadio Olimpico in Turin, where Gigi Del Neri hopes to end a negative streak.
The Bianconeri have to reinvent their midfield, as Alberto Aquilani and Momo Sissoko joined long-term absentees Leandro Rinaudo, Paolo De Ceglie and Fabio Quagliarella in the stands.
Claudio Marchisio therefore moves back into a more central role with Martinez placed wide left.
Gigi Buffon is also ruled out by a ban after his red card in the embarrassing 2-0 defeat to Lecce, so Storari takes the gloves.
It's a surprise change in attack, where Luca Toni is rested in favour of Iaquinta as a partner for Matri.
Bologna have Gaston Ramirez suspended plus Gyorgy Garics and the Juventus-owned Albin Ekdal injured, so Francesco Della Rocca is given the trequartista role behind Riccardo Meggiorini and Marco Di Vaio.
Miguel Angel Britos is still recovering from a facial injury and has been given a protective mask, but still starts in defence.
Juventus: Storari; Grygera, Barzagli, Bonucci, Chiellini; Krasic, Melo, Marchisio, Martinez; Iaquinta, Matri
Juventus bench: Manninger, Motta, Salihamidzic, Traoré, Pepe, Toni, Del Piero
Bologna: Viviano; Esposito, Portanova, Britos, Rubin; Perez, Mudingayi, Casarini; Della Rocca; Meggiorini, Di Vaio
Bologna bench: Lupatelli, Cherubin, Morleo, Mutarelli, Buscè, Gimenez, Paponi