Sampdoria are expected to fire Domenico Di Carlo today and replace the former Chievo boss with Alberto Cavasin.
Sunday's 3-2 defeat to relegation strugglers Cesena was Samp's seventh knockout in their last 10 games in Serie A.
The fans launched a series of protests before, during and after the game, unveiling a banner that said: "Di Carlo go now."
Around 150 ultras then attempted to storm the dressing room and had to be cleared. The players needed an escort to the team bus.
La Gazzetta dello Sport understands Di Carlo's dismissal will be made official today and that Alberto Cavasin is the favourite to step into the breach.
The 55-year-old has coached Fiorentina, Lecce and Brescian in the past. However, he faces competition for the post from Beppe Papadopulo, Gigi Cagni and Gianni De Biasi.