Andrea Pirlo picked up a thigh problem that could rule him out of the derby, while Ronaldinho is benched against Palermo once more.
Tonight San Siro hosts a huge game between Milan and the Rosanero, but the line-ups have some notable absentees.
Pirlo was rested for the 3-2 win at Bari on Sunday, but he picked up a thigh problem during training and there are fears he might not recover in time for the clash with Inter this weekend.
Ronaldinho has again been benched after watching the Bari game from the sidelines, as Kevin Prince Boateng returns from a ban to go straight into the starting XI.
Clarence Seedorf supports Zlatan Ibrahimovic and Alexandre Pato, so Robinho is dropped after his poor performance at the Stadio San Nicola.
Gennaro Gattuso is suspended, with Gianluca Zambrotta, Daniele Bonera and Massimo Oddo injured, but Mario Yepes gives Alessandro Nesta a rest.
Palermo have Fabrizio Miccoli on the bench, so the front three of Javier Pastore, Josip Ilicic and Mauricio Pinilla remain intact.
Milan: Abbiati; Abate, Yepes, Thiago Silva, Antonini; Flamini, Ambrosini, Boateng; Seedorf; Ibrahimovic, Pato
Palermo: Sirigu; Cassani, Munoz, Bovo, Balzaretti; Migliaccio, Bacinovic, Nocerino; Pastore, Ilicic; Pinilla