Napoli need a victory over the completely reshuffled Udinese to stay within three points of leaders Milan.
The Vesuviani take to the field in the final game of Week 33, which kicks off at 19.45 UK time.
Walter Mazzarri welcomes back Edinson Cavani from his ban to complete the trident with Ezequiel Lavezzi and Marek Hamsik.
There are no injury worries for the Coach to contend with and a solid squad for the final Scudetto push.
The same is not true of Udinese, who are torn apart ahead of this match and looking increasingly unlikely to catch Lazio in fourth place.
Star strikers Antonio Di Natale and Alexis Sanchez have not even made the trip due to injury, while midfielder Almen Abdi is suspended.
The Friulani therefore change to a new system with former Napoli centre-forward German Denis leading the way and a four-man defence.
Napoli: De Sanctis; Campagnaro, Cannavaro, Ruiz; Maggio, Pazienza, Yebda, Dossena; Hamsik, Lavezzi; Cavani
Udinese: Handanovic; Benatia, Zapata, Domizzi, Pasquale; Isla, Inler, Asamoah, Armero; Pinzi; Denis