Marco Borriello and Jeremy Menez face Samuel Eto'o and Giampaolo Pazzini in the Inter-Roma Coppa Italia semi-final.
The Nerazzurri have a foot in the Final already, as they won the first leg 1-0 at the Stadio Olimpico, so would have to lose on home turf to be eliminated.
Roma are weakened by bans to Francesco Totti and Rodrigo Taddei, while Philippe Mexes and Matteo Brighi are injured.
Daniele De Rossi and Simone Perrotta are available, as their bans only extend to Serie A football.
Marco Borriello is given a rare start in attack with Jeremy Menez, so Coach Vincenzo Montella sends Mirko Vucinic to the bench.
Inter are missing Wesley Sneijder and Dejan Stankovic due to injuries, the Serb a particular loss as he scored the winning goal in the first leg.
In defence Andrea Ranocchia is suspended, so Cristian Chivu shifts to centre-back alongside Lucio.
Houssine Kharja and MacDonald Mariga step in to take their places, with Yuto Nagatomo pushing Javier Zanetti into midfield.
It's a very special game for Zanetti, who tonight marks his 1,000th game as a professional football player.
The winners of this semi-final will face Palermo in the one-off Coppa Italia Final in Rome on May 29.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 26 Chivu, 55 Nagatomo; 19 Cambiasso, 17 Mariga; 4 Zanetti, 14 Kharja, 9 Eto'o; 7 Pazzini
Inter bench: 12 Castellazzi, 8 Thiago Motta, 20 Obi, 22 Milito, 23 Materazzi, 27 Pandev, 29 Coutinho
Roma: 32 Doni; 77 Cassetti, 29 N. Burdisso, 4 Juan, 17 Riise; 7 Pizarro, 16 De Rossi; 20 Perrotta, 30 Simplicio, 94 Menez; 22 Borriello
Roma bench: 1 Lobont, 3 Castellini, 9 Vucinic, 15 Loria, 23 Greco, 47 Caprari, 87 Rosi