Napoli start Arkadiusz Milik with Lorenzo Insigne, resting Dries Mertens, in their Champions League opener with Shakhtar Donetsk.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on the LIVEBLOG.
The Partenopei qualified for the tournament via the play-offs, crushing Nice 4-0 on aggregate, and have won their last 10 competitive matches.
They also started their European group stage in Ukraine last year, beating Dynamo Kiev 2-1 with a Milik brace.
The Poland international leads the way again, resting Mertens from the trident with Insigne and Jose Callejon.
Marek Hamsik commands the midfield with Amadou Diawara stepping in for Jorginho and Piotr Zielinski rather than Allan. The captain is just two goals away from matching Diego Armando Maradona’s all-time Napoli scoring record of 115.
Shakhtar Donetsk are the champions of Ukraine, but only recently started playing at the OSK Metalist Stadion in Kharkiv.
They had been hosted by Lviv after their own Donbass Arena was damaged by shelling during the conflict with Russia in 2014 and the club headquarters, including training ground, have moved to Kiev.
Coach Paulo Fonseca is without centre-back Serhiy Krystov for six to eight weeks after he fractured his kneecap in Saturday’s 3-1 win over Zorya.
Ivan Ordets is also carrying a knock, but starts anyway, and midfielder Maksym Malyshev is out of action.
The biggest danger in attack is Argentine striker Facundo Ferreyra, supported by Brazilians Fred, Marlos, Taison and Bernard.
Shakhtar Donetsk: Pyatov; Srna, Ordets, Rakitskiy, Ismaily; Stepanenko, Fred; Marlos, Bernard, Taison; Ferreyra
Shakhtar bench: Shevchenko, Butko, Khocholava, Marcio Azevedo, Patrick, Petriak, Dentinho, Kovalenko
Napoli: Reina; Hysaj, Albiol, Koulibaly, Ghoulam; Zielinski, Diawara, Hamsik; Callejon, Milik, Insigne
Napoli bench: Sepe, Maksimovic, Maggio, Rog, Allan, Jorginho, Mertens
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