Atalanta have already qualified for the Europa League knockouts, but have the chance to top the group ahead of Olympique Lyonnais.
It kicks off at the Mapei Stadium at 18.00 GMT, follow the build-up and action from this game, Rijeka-Milan and Zulte Waregem-Lazio on the LIVEBLOG.
Both these sides have already secured their qualification for the Round of 32, so the only thing at stake here is topping the group and the hope of a better draw.
Gian Piero Gasperini’s minnows were expected to struggle in their first continental competition for 28 years, but only need a draw tonight to pip Lyon to top spot.
That’s because they drew 1-1 in France and have an identical record, but Atalanta have the superior goal difference.
Fresh from a 5-1 demolition job on Everton at Goodison Park, the Orobici are fired up and start big names Papu Gomez, Bryan Cristante, Josip Ilicic and Andrea Petagna.
Lyon risk Nabil Fekir, who is not 100 per cent fit, and use Maxwell Cornet and Memphis Depay in support of centre-forward Mariano Diaz.
Bertrand Traore hasn’t made the trip.
Atalanta: Berisha; Toloi, Caldara, Masiello; Hateboer, Cristante, Freuler, Spinazzola; Gomez, Petagna, Ilicic
Atalanta bench: Gollini, Palomino, Castagne, Orsolini, Cornelius, De Roon, Kurtic
Olympique Lyonnais: Lopes; Rafael, Diakhaby, Marcelo, Mendy; Ndombele, Ferri; Cornet, N Fekir, Depay; Diaz
Lyon bench: Gorgelin, Yanga-Mbiwa, Aouar, Gouiri, Marcal, Tete, Tousart
Ref: Eskov (RUS)