Juventus have the chance to leapfrog Inter into second place, but drop Paulo Dybala again and have a decimated squad against Bologna.
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The Bianconeri can take advantage of Inter’s surprise 3-1 home defeat to Udinese, just as Napoli already have to recapture the top of the table.
However, Max Allegri has quite a few problems to contend with at the Stadio Dall’Ara.
Gigi Buffon, Giorgio Chiellini, Stephan Lichtsteiner, Juan Cuadrado and Benedikt Howedes haven’t even made the trip due to injury.
Dybala is fully fit, but the Coach announced his plans to drop him for the second game running, an attempt to spark a reaction against his current poor form.
It’s a tactic that worked with Gonzalo Higuain, but will it convince La Joya to shake off his malaise?
Meanwhile, Douglas Costa and Mario Mandzukic again support Pipita, with Miralem Pjanic available again in midfield.
Bologna have already taken points off Inter here this season and were unlucky not to win that match, but Roberto Donadoni is missing experienced forward Rodrigo Palacio and talented winger Federico Di Francesco.
Teenage hitman Orji Okwonkwo has scored three goals off the bench this term and gets only his second ever Serie A start. Curiously, the first was also this fixture, which Juve won 2-1.
Okwonkwo supports Mattia Destro and free kick specialist Simone Verdi. Andrea Poli has finished his ban and can bolster the midfield.
Bologna have won just two of their last 37 meetings with Juventus across all competitions (2-0 in Turin in February 2011).
The Rossoblu haven’t beaten the Bianconeri on home turf since November 29, 1998, scraping only five draws from 16 attempts.
Bologna: Mirante; Mbaye, Helander, Gonzalez, Masina; Poli, Pulgar, Donsah; Verdi, Destro, Okwonkwo
Juventus: Szczesny; De Sciglio, Benatia, Barzagli, Alex Sandro; Khedira, Pjanic, Matuidi; Douglas Costa, Higuain, Mandzukic