Juventus drop Paulo Dybala yet again, but have Mario Mandzukic and Juan Cuadrado back against Edin Dzeko and Stephan El Shaarawy’s Roma.
It kicks off at 19.45 GMT, follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
This is a Scudetto showdown, as Juve are currently in second place and the Giallorossi are fourth, but with a game in hand.
Max Allegri is without Gigi Buffon, Mattia De Sciglio and Benedikt Howedes, so Wojciech Szczesny starts against his old club, as do Medhi Benatia and Miralem Pjanic.
Dybala was dropped for two Serie A rounds in a row and broke his goal drought in the Coppa Italia win over Genoa midweek.
Nonetheless, La Joya is sent to the bench yet again, as he doesn’t fit in the new 4-3-3 system alongside Gonzalo Higuain.
Mandzukic and Cuadrado have shaken off injuries, sending Douglas Costa and Federico Bernardeschi back to the touchline.
Juventus could also push Andrea Barzagli to right-back, in effect a three-and-a-half-man defence, often used in the Champions League.
Roma are missing Gregoire Defrel and Rick Karsdorp, but otherwise have a full squad to choose from.
Eusebio Di Francesco rarely strays from his beloved 4-3-3 system but, unlike mentor Zdenek Zeman, he makes sure the defence is solid.
In fact, they have the best defensive record in Serie A this season, while Juve are the most prolific in attack.
Alessandro Florenzi gets the right-back spot with Daniele De Rossi available again after suspension.
El Shaarawy and Diego Perotti flank centre-forward Edin Dzeko, leaving Patrik Schick on the bench.
Roma have lost their last six Serie A trips to Turin, managing one point since a 2-1 victory in January 2010.
Juventus: Szczesny; Barzagli, Benatia, Chiellini, Alex Sandro; Pjanic, Khedira, Matuidi; Cuadrado, Higuain, Mandzukic
Juventus bench: Pinsoglio, Loria, Lichtsteiner, Rugani, Asamoah, Marchisio, Bentancur, Sturaro, Dybala, Douglas Costa, Bernardeschi, Pjaca
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Strootman; El Shaarawy, Dzeko, Perotti
Roma bench: Skorupski, Lobont, Juan Jesus, Peres, Castan, Moreno, Emerson, Gonalons, Pellegrini, Gerson, Under, Schick
Watch Serie A live in the UK on Premier Sports for just £11.99 per month including live LaLiga, Eredivisie, Scottish Cup Football and more. Visit: https://subscribe.premiersports.tv/