Lazio have Felipe Caicedo and Felipe Anderson up against Fiorentina’s Khouma Babacar in the Coppa Italia Quarter-Final.
It kicks off at the Stadio Olimpico at 20.00 GMT and the winners go on to face Milan or Inter in the two-legged semi-final in January and February.
These sides already met in a controversial 1-1 draw in Rome on November 26, as Stefan de Vrij had put the Aquile ahead, but Babacar converted a 94th-minute penalty awarded via VAR.
It was a decision that infuriated Lazio so much, they released a statement suggesting attempts to “damage” their season.
Now ex-Biancocelesti Coach Stefano Pioli returns to the Olimpico with a place in the Coppa Italia semi-final at stake.
This fixture was the Final on two occasions, in 1958 and 1961.
Simone Inzaghi fields practically a first-choice XI with Sergej Milinkovic-Savic, Lucas Leiva and fit-again Felipe Anderson.
Ciro Immobile is suffering from flu symptoms and therefore not risked in the starting XI.
Davide Di Gennaro is the only absentee, as Luis Alberto is rested and Luis Nani only fit for the bench.
Fiorentina are a little more versatile, even though they do not have any European commitments to worry about this term.
Babacar has been on strong form coming off the bench and is given a rare start with Riccardo Saponara and Federico Chiesa.
Lazio: Strakosha; Bastos, De Vrij, Radu; Basta, Parolo, Leiva, Milinkovic-Savic, Lulic; Felipe Anderson; Caicedo
Fiorentina: Dragowski; Gaspar, Milenkovic, Vitor Hugo, Astori; Chiesa, Veretout, Sanchez, Benassi; Saponara; Babacar