Domenico Berardi picked up an injury in training and could be on the Sassuolo bench against Roma tomorrow.
It kicks off on Saturday at 14.00 GMT, click here for a match preview.
The Neroverdi are already forced to do without injured Claud Adjapong, Stefano Sensi, Davide Biondini and Timo Letschert.
Berardi pulled up during today’s training session and remains in doubt for the big game.
It’s reported he is likely to be rested, at least to begin with, as Antonino Ragusa steps into the trident attack with Diego Falcinelli and Matteo Politano.
Sassuolo squad for Roma: Consigli, Marson, Pegolo; Peluso, Acerbi, Lirola, Gazzola, Goldaniga, Rogerio, Cannavaro, Dell’Orco; Magnanelli, Mazzitelli, Missiroli, Frattesi, Cassata, Duncan; Matri, Falcinelli, Politano, Pierini, Berardi, Ragusa