Leaders Napoli are without Marek Hamsik due to flu symptoms in this difficult trip to Atalanta, as Andreas Cornelius partners Papu Gomez.
It kicks off in Bergamo at 11.30 GMT, follow the build-up and action from all nine Serie A games on the LIVEBLOG.
Gian Piero Gasperini’s men have won three of their last four meetings with Napoli, including a Coppa Italia quarter-final earlier this month, so are a real taboo for Maurizio Sarri.
The Orobici are eager to cause another upset, but are missing suspended Marten De Roon.
Andrea Petagna is dropped in favour of Cornelius, who scored against Napoli in that Coppa Italia 2-1 result at the Stadio San Paolo on January 2.
Papu Gomez leads the attack, as always, with Josip Ilicic and Bryan Cristante providing the creativity.
Napoli welcomed Faouzi Ghoulam and Arkadiusz Milik back to training this week, but they aren’t ready to take part yet after several months out with torn anterior cruciate ligaments.
Hamsik missed training for several days this week due to tonsillitis and flu symptoms, so the captain is rested in favour of Piotr Zielinski.
Dries Mertens, Jose Callejon and Lorenzo Insigne lead the way, well-rested after the Winter break.
Atalanta have found the net in each of their last eight Serie A encounters with Napoli and are their real taboo team.
Atalanta: Berisha; Toloi, Caldara, Masiello; Hateboer, Cristante, Freuler, Spinazzola; Ilicic; Gomez, Cornelius
Napoli: Reina; Hysaj, Albiol, Koulibaly, Mario Rui; Allan, Jorginho, Zielinski; Callejon, Mertens, Insigne
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