Roma rely on Patrik Schick and Cengiz Under, as Milan look to Patrick Cutrone and Hakan Calhanoglu in tonight’s big game.
It kicks off at the Stadio Olimpico at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
Juventus-Atalanta was snowed off this evening and the timing here was crucial, because tomorrow schools in Rome are closed due to snow warnings in the Capital.
Going into this weekend, the Giallorossi were in fourth place and the Diavolo joint sixth with nine points separating them, so it’s a head-to-head for European ambitions.
Gennaro Gattuso has revitalised his men since taking over from Vincenzo Montella and a top four finish is not entirely out of the question.
They are also in the Europa League Round of 16 against Arsenal and visit Lazio for the second leg of the Coppa Italia semi-final on Wednesday.
Luca Antonelli and Andrea Conti are out injured, while teenage striker Cutrone is again preferred to Nikola Kalinic and Andre Silva, having contributed 13 goals and four assists in 31 competitive games this season.
He is flanked by Suso and Hakan Calhanoglu, with Jack Bonaventura, Franck Kessie – returning from suspension – and Lucas Biglia in midfield.
It’s a special evening for Gianluigi Donnarumma, as the goalkeeper turns 19 today.
Roma were also in European action this week, on Wednesday leading at Shakhtar Donetsk in the Champions League only to fall apart in the second half and lose 2-1.
Cengiz Under was on target again in that Round of 16 tie, meaning he has scored four goals in the last three official matches.
The Turkish teen cannot be dropped on his current form, but Edin Dzeko can, so Schick gets a rare start as the centre-forward with Diego Perotti in support.
Alessandro Florenzi is still not fully fit after coming down with a stomach bug in Ukraine, so Bruno Peres is given the nod at right-back.
Rick Karsdorp and Maxime Gonalons are the usual absentees, but January buy Jonathan Silva is on the bench for the first time.
Milan have not beaten Roma at the Stadio Olimpico in Serie A since a 3-2 result in October 2011, when Zlatan Ibrahimovic and Alessandro Nesta were on target.
That was followed by two draws and three defeats.
There is another issue to be concerned about, as next week is the Derby della Madonnina with Inter and Leonardo Bonucci is one yellow card away from suspension.
Roma: Alisson; Bruno Peres, Manolas, Fazio, Kolarov; Pellegrini, Strootman, Nainggolan; Under, Schick, Perotti
Roma bench: Skorupski, Lobont, Florenzi, Juan Jesus, Capradossi, Silva, De Rossi, Gerson, Defrel, El Shaarawy, Dzeko
Milan: G Donnarumma; Calabria, Bonucci, Romagnoli, Rodriguez; Kessie, Biglia, Bonaventura; Suso, Cutrone, Calhanoglu
Milan bench: A Donnarumma, Guarnone, Abate, Musacchio, Gomez, Zapata, Locatelli, Montolivo, Mauri, Borini, Andre Silva, Kalini
See the latest Serie A predictions and betting tips with Eurotips.co.uk