Paulo Dybala returns from the start, but Mario Mandzukic is in doubt, while Lazio have Adam Marusic suspended and changes in defence.
It kicks off today at 17.00 GMT, click here for a match preview.
Coach Max Allegri confirmed Dybala will be in the starting XI after his long lay-off for a hamstring strain, but Mandzukic is reportedly a late addition to the absentee list due to a muscular issue in training on Friday.
Paulo Dybala returns from the start, but Mario Mandzukic is in doubt, while Lazio have Adam Marusic suspended and changes in defence.
It kicks off today at 17.00 GMT, click here for a match preview.
Coach Max Allegri confirmed Dybala will be in the starting XI after his long lay-off for a hamstring strain, but Mandzukic is reportedly a late addition to the absentee list due to a muscular issue in training on Friday.
With Gonzalo Higuain, Federico Bernardeschi, Juan Cuadrado and Mattia De Sciglio already out, this limits the options in attack.
Douglas Costa therefore takes the right-wing role in the trident with Alex Sandro again pushed into a more advanced role on the left.
Lazio played 120 minutes and a sudden death penalty shoot-out on Wednesday night before capitulating to Milan in the Coppa Italia semi-final.
Fatigue is bound to be an issue, especially injured Martin Caceres and suspended Marusic in midfield.
Dusan Basta is expected to step in for Marusic on the wing, with Wallace taking over from Luiz Felipe in defence.
Probable line-ups
Lazio: Strakosha; Wallace, De Vrij, Radu; Basta, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Immobile
Lazio bench: Guerrieri, Vargic, Bastos, Luiz Felipe, Patric, Murgia, Crecco, Jordao, Lukaku, Nani, Felipe Anderson, Caicedo
Juventus: Buffon; Lichtsteiner, Benatia, Rugani, Asamoah; Khedira, Pjanic, Matuidi; Douglas Costa, Dybala, Alex Sandro
Juventus bench: Szczesny, Barzagli, Chiellini, Howedes, Sturaro, Bentancur, Marchisio, Del Favero, Mandzukic