Juventus rely on Gonzalo Higuain, Paulo Dybala, Douglas Costa and some tactical adjustments in their Champions League clash with Harry Kane’s Tottenham.
It kicks off at Wembley Stadium at 19.45 GMT.
The first leg ended 2-2 in Turin, as Higuain had given the Bianconeri an early 2-0 lead, only to then miss a penalty, followed by a remarkable comeback from Kane and Christian Eriksen.
Higuain has been out of action since spraining his ankle in the Turin Derby on February 18, but has trained for the last two days and is thrown straight into the starting XI.
Max Allegri has to take the risk, because the only other centre-forward in the squad – Mario Mandzukic – was left behind on the treatment table in Turin.
Dybala was out for two months with a hamstring strain and missed the first leg, but proved his fitness by playing over 90 minutes in Saturday’s 1-0 win over Lazio, scoring the spectacular last-gasp winning goal.
Options in attack are limited, as Douglas Costa is not 100 per cent fit either, while Federico Bernardeschi and Juan Cuadrado are injured.
It was thought initially that Douglas Costa would start from the bench, but his presence allows the Bianconeri to use a very fluid tactical system.
With Andrea Barzagli chosen rather than Mattia De Sciglio or Stephan Lichtsteiner, Juve can use the same players to move from 3-5-2 to 4-4-2 or 4-3-2-1, depending on the circumstances.
Alex Sandro can be a left-back or push further up down the flank into a wide midfield role.
Blaise Matuidi is back in action after missing the first leg and partners Sami Khedira and Miralem Pjanic.
Tottenham have to do without injured Toby Alderweireld and suspended Serge Aurier, although some Spurs fans would argue Aurier’s absence is more of a bonus than a hindrance.
It means Kieran Trippier gets his first Champions League start at right-back.
Mousa Dembele shakes off a knock to start in midfield, so Lucas Moura goes to the bench with former Roma man Erik Lamela.
It’s all about the attack and Mauricio Pochettino has Eriksen, Dele Alli and Son Heung-Min fanning out behind on-form hitman Kane.
South Korea international Son might be the least famous of the quartet, but he has scored a brace in each of his last two competitive games.
Spurs have won all three home games in the Champions League this season, including victories over Borussia Dortmund and Real Madrid.
They are unbeaten at Wembley in 15 games, winning the last seven on the trot, and kept eight clean sheets in the last 12 here.
Tottenham: Lloris; Trippier, Sanchez, Vertonghen, Davies; Dier, Dembele; Eriksen, Alli, Son; Kane
Tottenham bench: Gazzaniga, Rose, Lamela, Wanyama, Sissoko, Llorente, Lucas
Juventus: Buffon; Barzagli, Benatia, Chiellini, Alex Sandro; Khedira, Pjanic, Matuidi; Douglas Costa, Dybala; Higuain
Juventus bench: Szczesny, Marchisio, Asamoah, Rugani, Lichtsteiner, Sturaro, Bentancur
Ref: Marciniak (POL)
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